https://bugs.freedesktop.org/show_bug.cgi?id=93970
--- Comment #4 from Ilia Mirkin imirkin@alum.mit.edu --- There's a drirc entry for Second Life already:
<application name="Second Life" executable="do-not-directly-run-secondlife-bin"> <option name="allow_glsl_extension_directive_midshader" value="true" /> </application>
You could just add the other option there as well - no need to set them globally (in fact, it might cause other things to break as a result - various exts can cause older shaders to become invalid, as keywords are added/etc).