https://bugs.freedesktop.org/show_bug.cgi?id=74539
--- Comment #7 from Nick Tenney nick.tenney@gmail.com --- I found this helpful for setting up wine and valgrind together:
http://wiki.winehq.org/Wine_and_Valgrind
You may need to recompile wine after installing valgrind, as mentioned in the wiki. For a similar issue in Diablo III, I could not get the game to run with valgrind, so I used apitrace to record a session and ran valgrind on the trace (after much help from Michel and Ilia). Hope this helps. Oh, make sure to compile Mesa with debug symbols or you'll need to repeat the whole process. I forgot that the first time 'round.