Comment # 79 on bug 110659 from Pierre-Eric Pelloux-Prayer

(In reply to Michel Dänzer from comment #76)
> (In reply to tempel.julian from comment #75)
> > Is it possible that Wine or the affected programs in Wine are the clients
> > that are at fault for this?
> 
> Certainly. It looks like the intention is to prevent the monitors from
> entering power saving mode.

Maybe the code from this wine patch
https://www.winehq.org/pipermail/wine-devel/2018-July/129014.html
("winex11.drv: Wake up the display on user input") is causing this?

(adding a breakpoint in wine for the XResetScreenSaver function should confirm)