I managed to make it work somehow, but it's still unusable due to producing artifacts on images processed using opencl on darktable and few other programs I tried. So probably the title should be changed. However, CL_OUT_OF_HOST_MEMORY error may be removed via envitonment var setting, namely export GPU_FORCE_64BIT_PTR=1 also export GPU_USE_SYNC_OBJECTS=1 export GPU_MAX_ALLOC_PERCENT=100 export GPU_SINGLE_ALLOC_PERCENT=100 export GPU_MAX_HEAP_SIZE=100 are recommended but I haven't noticed any difference. What I've noticed, however, is that the driver reports the different amount of available GPU memory each time darktable is started...