With Mesa 10.1.0-devel (git-0601598) & LLVM 3.4 (svn-r195266) still quits in the same moment but log is a little bit different: Sam3: AMDGPUInstrInfo.cpp:113: virtual void llvm::AMDGPUInstrInfo::storeRegToStackSlot(llvm::MachineBasicBlock&, llvm::MachineBasicBlock::iterator, unsigned int, bool, int, const llvm::TargetRegisterClass*, const llvm::TargetRegisterInfo*) const: Assertion `!"Not Implemented"' failed. I don't try Brutal Legent, but Stalker game(by the wine) has the same issue and log changes from AMDGPUInstrInfo.cpp:113 to AMDGPUInstrInfo.cpp:109 after update mesa/llvm too.