I also have this behavior on Linux 4.7.2 I tried either to unbind on /sys/bus/pci/drivers/amdgpu/unbind or remove the device and trigger a rescan using /sys/bus/pci/devices/.../remove, /sys/bus/pci/rescan. I have kernel panics and/or system hangs either way. It would be awesome to be able to yield the GPU to a VM then claim it back when finished.